Blood Clots May Be the Root Cause of All Heart Disease

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On this interview, repeat visitor Dr. Malcolm Kendrick, a board-certified household doctor and creator of the ebook, “The Clot Thickens: The Enduring Mystery of Heart Disease,” critiques the underlying mechanisms for coronary heart illness, which for the final century has been the main reason behind loss of life within the U.S.

Of all of the books he’s written, that is my favourite, because it goes into nice element, supplying you with the organic understanding of the method of atherosclerosis resulting in coronary heart assaults and strokes. He additionally has stable methods for reducing your heart problems danger.

By the way, when you perceive the illness course of, then you may also perceive how each COVID-19 and the COVID jab can contribute to coronary heart illness. When requested why he’s taken such an curiosity in coronary heart illness, Kendrick replies:

“Once I was coaching as a scholar in drugs, Scotland had the very best charge of coronary heart illness on the earth. Early on the reply for why was, ‘Oh, effectively, it is as a result of we’ve such horrible eating regimen, and we eat garbage meals like deep fried Mars bars.’

So, you eat an excessive amount of saturated fats, the saturated fats will get changed into ldl cholesterol in your bloodstream, after which it’s absorbed into arteries and kinds narrowings and thickenings, which all sounds believable if you happen to do not give it some thought too exhausting.

However I additionally occur to go to France quite a bit, and what I seen about France was, they eat a variety of saturated fats. They eat extra, in truth, than anybody else in Europe, and positively greater than Scotland. So, [this saturated fat] speculation actually did not work for the French. They’ve the very best saturated fats consumption in Europe and lowest charge of coronary heart illness, and this has been the case for many years.

If you happen to took all the danger elements for France and Scotland [such as smoking, high blood pressure and diabetes], then the French had barely [higher risk], based on standard pondering. However, in truth, they’d one-fifth [the rate among age-matched men].

So, I believed, that is fascinating. It does not make a lot sense based on what we’re informed. Then whereas I used to be in medical faculty, a tutor in cardiology mentioned … LDL can’t cross the endothelium. On the time, I did not know what LDL was, nor did I do know what the endothelium was, however it sounded essential.

She had been taking a look at coronary heart illness as a distinct course of for many years … So, I believe that is actually the place I acquired began. When you begin questioning what the issue is, you find yourself questioning an increasing number of and also you begin pondering, gosh, that is simply nonsense, is not it? This complete speculation is simply nonsense. So, I began selecting it aside.”

The Thrombogenic Speculation

“The Clot Thickens” is Kendrick’s effort to elucidate another speculation for what truly causes coronary heart illness. If it’s not saturated fats and ldl cholesterol, what’s it? In 1852, a Viennese researcher, Karl von Rokitansky, developed what he known as the encrustation speculation of coronary heart illness.

At present, this speculation has been renamed the thrombogenic speculation. ‘Thrombo’ stands for thrombosis, i.e., blood clots, and ‘genesis’ means the reason for, or the beginning of. So, the thrombogenic speculation is that blood clots are the essential pathology that causes all coronary heart illness.

In a nutshell, when a blood clot kinds in your artery wall, which might occur for plenty of causes, it’ll usually be coated over and dissolved. An issue arises, nonetheless, if the blood clot will not be absolutely eradicated and one other blood clot kinds in the identical ‘weak’ space. This then turns into what’s conventionally known as atherosclerotic plaque.

“The atherosclerotic plaque is mainly a buildup of blood clot, restore, blood clot, restore, blood clot, restore,” Kendrick explains. “If the blood clotting course of is quicker than the restore course of, you have got a plaque that progressively grows and ultimately thickens the artery wall till it narrows sufficiently that the ultimate blood clot, on prime of the present plaque, is the factor that may trigger a coronary heart assault or stroke …

If you happen to lower by the plaque and take a look at it, it virtually seems to be like tree rings. You may see there’s been a clot, restore, clot, restore, clot, restore, clock, restore through the years.

It’s extensively accepted {that a} blood clot forming on an current plaque will trigger the plaque to develop in dimension. You could find 10,000 papers saying that that is the case. What the mainstream will not settle for is {that a} blood clot on a wholesome artery wall can provoke the entire course of.

So, to an extent, all I am saying to individuals is, effectively, we all know blood clots trigger the ultimate occasion. We all know blood clots trigger plaques to develop. Why will not you settle for that blood clots are the factor that begins it within the first place? As a result of then we’ve one course of right through, and it is sensible, as a result of it suits with what you possibly can see.”

As famous by Kendrick, the traditional view is that low-density lipoprotein or LDL will get into the artery wall the place it initiates plaque formation. It then, inexplicably, stops initiating plaque, and the plaque continues to develop by the addition of repeated clots.

Nonetheless, Kendrick says, when you begin drilling down into the ldl cholesterol, aka LDL speculation, the entire thing begins to collapse. LDL merely can’t clarify the illness development. But regardless of the numerous holes within the idea, the concept LDL causes coronary heart illness is touted as an absolute, proven fact.

What’s the Mechanism?

With a purpose to justify a speculation, that you must have a mechanism of motion. When you perceive the mechanism of the particular illness course of, then you possibly can put the puzzle items collectively. Kendrick begins his rationalization:

“Your blood vessels are lined with endothelial cells, a bit like tiles on a wall. Endothelial cells are additionally coated themselves in a factor known as glycocalyx. If you happen to attempt to choose up a fish, it’s going to slip by your fingers; it’s extremely slippery. The explanation it is slippery is as a result of it’s coated in glycocalyx and the glycocalyx is extremely slippery. It is nature’s Teflon.

So mainly, in our case, the glycocalyx [is inside] our blood vessels, to permit the blood to journey by with out it sticking, with out harm occurring. So, you have got this type of damage-repellent layer on prime of your endothelial cells.

Now, if that layer is broken, after which the endothelial cell itself beneath is broken, then the physique will say, ‘Oh, we have harm to a blood vessel, we will need to have a blood clot there as a result of we may bleed out.’ So, a blood clot kinds on the realm of harm, and instantly stops [the bleeding].”

The blood clot doesn’t simply carry on rising and rising. If it did, you’d die anytime you had a blood clot. As an alternative, when a clot kinds, different processes step in to stop it getting too large, which is why each blood clot doesn’t trigger a stroke or coronary heart assault. As soon as the clot has stabilized, and has been shaved down, the realm is roofed over by endothelial progenitor cells, made within the bone marrow, that float round in your blood stream.

When a progenitor cell finds an space that has been broken, it attaches itself to that space, together with others, forming a brand new endothelial layer. The remaining blood clot is now mendacity ‘inside’ the artery wall itself. So, mainly, it’s the restore course of that may result in plaque buildup inside the artery wall. In time, if harm outstrips restore, this may slim the artery and scale back blood movement.

What Damages Endothelial Cells?

The query is, what can harm the endothelium within the first place? Right here, Kendrick makes use of the SARS-CoV-2 mechanism for instance:

“The COVID virus enters endothelial cells by the ACE2 receptor. It prefers endothelial cells as a result of they have ACE2 receptors on them. It will get into the endothelial cell and begins replicating, then bursts out, damaging the cell. Bingo, you’ve acquired an space of harm.

After all, added to this, when cells have viruses inside them, they ship out misery alerts to the immune system saying, ‘I have been contaminated, come and kill me,’ and so the immune system begins to have a go on the endothelial cells. Because of this you will get an issue, as a result of the endothelial cells are being broken and stripped off.

Blood clotting happens on the factors of harm and hey, presto, you are having clotting, you are having strokes, you are having coronary heart assaults, which is the factor that individuals at first could not perceive [about COVID-19]. But it’s extremely clear that what’s occurring is you’ve got acquired harm to the endothelial cells.

Clearly, you and I each know that if you happen to get a [COVID jab], the cells are triggered to provide the spike protein, and these cells are sending out misery messages saying, ‘I’m contaminated.’ It’s important to be very cautious if you wish to stick one thing into cells that then says to the immune system, ‘Please come and destroy me,’ as a result of that is what the immune system goes to do.

However transferring on from that, what different factor may cause endothelial harm? The reply is issues like smoking. Smoke particles get out of your lungs, they go into your blood vessels they usually trigger harm … You smoke one cigarette and an entire bunch of microparticles seem in your bloodstream, which suggests endothelial cells are dying.

Fortunately as endothelial cells die, one other message is shipped to the bone marrow saying, we want extra endothelial cells and it stimulates endothelial progenitor cell manufacturing. These endothelial progenitor cells rush round protecting over the areas of harm.

Some people who smoke have sufficient restore happening and if you’re youthful, it is okay. As you become old and your restore techniques start to fail a bit, cigarette smoking turns into an increasing number of of an issue.”

Different issues that may trigger endothelial harm embrace:

Repairing the Glycocalyx

As defined by Kendrick, the glycocalyx layer resembles a garden, with slippery filaments that stick up. Inside this glycocalyx layer you have got nitric oxide synthase (NOS), which produces nitric oxide (NO), and you’ve got NO itself, in addition to plenty of different anticoagulant proteins. The glycocalyx is definitely a potent anticoagulant layer, so it stops blood clots forming. If glycocalyx is broken, your danger of blood clotting will increase.

“It’s a really sophisticated layer,” Kendrick says. “It is like a jungle filled with issues that say, ‘Do not keep on with this, steer clear of this.’” Inside it, you even have albumin, protein complicated produced by the liver. Albumin comprises the proteins that assist preserve and restore the glycocalyx. A reality that almost all docs are unaware of is that, when you have a low albumin stage, you are considerably extra more likely to die of coronary heart illness.

The excellent news is that whereas the glycocalyx layer will be quickly destroyed, it can be quickly repaired. (Experiments have proven that in an space the place the glycocalyx has been utterly stripped off, it may be utterly repaired in a single second.) Dietary supplements like chondroitin sulfate and methylsulfonylmethane (MSM) will be useful on this regard.

“If you happen to try to clarify that by the LDL mechanism, it simply does not work,” Kendrick says. “They’ve found that if you happen to give chondroitin sulfate as a complement — which usually is for arthritis and stuff like that — it reduces the danger of coronary heart illness fairly significantly. How do you clarify that? Effectively, you possibly can clarify that since you’re defending your glycocalyx.

These are the kind of issues that make no sense if you happen to like trying on the standard concepts of coronary heart illness, however are instantly and simply defined if you happen to say, ‘We’ve got to maintain our glycocalyx wholesome and we’ve to maintain our endothelial cells beneath them wholesome.

In any other case they are going to be broken and stripped off, after which we are going to get a blood clot, and if we maintain getting blood clots at that time, we are going to find yourself with a plaque and ultimately one of many blood clots on that plaque will kill you from a coronary heart assault or a stroke.”

Blood Circulate Restriction Coaching

A life-style technique that may assist restore endothelial harm is blood movement restriction (BFR) coaching. In response to BFR, your physique produces vascular endothelial development issue (VEGF), which acts as “fertilizer” for the endothelium. You may be taught the ins and outs of BFR in my free BFR report. VEGF additionally induces the synthesis of nitric oxide (NO), a potent vasodilator, and it stimulates endothelial progenitor cells.

“NO protects the endothelium. It’s anticoagulant — probably the most potent anticoagulant we’ve within the physique. It’s actually the magic molecule for cardiovascular well being,” Kendrick says.

“At one time NO was generally known as Endothelial Derived Rest Issue (EDRF) NO was one thing nobody believed may presumably exist within the human physique. NO is definitely a free radical. Everybody says free radicals are terribly damaging and unhealthy.

To that I reply, ‘Effectively, it’s possible you’ll want to know that the chemical that’s the single most essential protecting chemical within the physique for the cardiovascular system is an extremely free radical known as nitric oxide.”

Some anticancer medication are designed to dam VEGF, because the tumor wants angiogenesis — which is the creation of recent blood vessels which are required to supply ample ‘vitamins’ With out these new blood vessels, the tumor dies off. Sadly, if you happen to block VEGF, you additionally block NO, which then raises your danger for coronary heart illness.

“These medication have been virtually faraway from the market,” Kendrick says, “as a result of regardless of their anticancer exercise, they have been procardiovascular illness to fairly a scary diploma.

[That’s why], in case you are given bevacizumab or Avastin as an anticancer drug, they now offer you angiotensin changing enzyme inhibitors (ACE inhibitors), that are blood stress reducing tablets, and ACE inhibitors have a selected influence on bradykinin, which will increase NO synthesis.”

Methods to Decrease Your Thrombotic Danger

In his ebook, “The Clot Thickens: The Enduring Mystery of Heart Disease,” Kendrick critiques many alternative methods that may decrease your illness danger. Right here’s a short-list of examples coated in far larger depth within the ebook, in addition to a few of my very own suggestions that I carry up within the interview:

Keep away from pointless use of nonsteroidal anti-inflammatories (NSAIDs) corresponding to ibuprofen, aspirin and naproxen — Whereas they successfully inhibit irritation, they’ll trigger platelet aggregation by blocking COX-2. In different phrases, they activate your blood clotting system, making blood clots extra seemingly.

Get loads of smart solar publicity — Solar publicity triggers NO that helps dilate your blood vessels, reducing your blood stress. NO additionally protects your endothelium, and will increase mitochondrial melatonin to enhance mobile vitality manufacturing.

Keep away from seed oils and processed meals — Seed oils are a major supply of the omega-6 fats known as linoleic acid (LA), which I imagine could also be way more dangerous than sugar. Extreme consumption is related to most all power illnesses, together with hypertension, weight problems, insulin resistance and diabetes. LA will get embedded in your cell membranes, inflicting oxidative stress, and might stay there for as much as seven years. Oxidative linoleic acid metabolites (OXLAMs) are what’s inflicting the first harm, together with endothelial harm.

Decrease your insulin and blood sugar ranges — Easy methods to perform this embrace time-restricted consuming, consuming a eating regimen excessive in wholesome fat and low in refined carbohydrates, considerably limiting your LA consumption and getting common train.

Tackle power stress, which raises each blood sugar and blood stress, promotes blood clotting and impairs your restore techniques. Cortisol, a key stress hormone, reduces endothelial cell manufacturing.

Give up smoking.

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